Реакция #82331

Уравнение реакции

[N-(benzyloxycarbonyl)-L-phenylalanyl]methyl bromide

N2 L-prolyl-N1 -isobutyl-L-isoleucinamide

triethylamine

→

N2 [N-[[N-(benzyloxycarbonyl)-L-phenylalanyl]methyl]-L-prolyl]-N1 -isobutyl-L-isoleucinamide

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   ДругоеThe solvent was removed by evaporation
2. 2
   Другоеthe crude product was chromatographed on silica gel
3. 3
   Промывкаfor the elution
4. 4
   ДругоеThe resulting product was triturated with a mixture of petroleum ether (b.p. 40°-60° C.) and ethyl acetate

Методика

A solution of 8.86 g of [N-(benzyloxycarbonyl)-L-phenylalanyl]methyl bromide 6.71 g of N2 -L-prolyl-N1 -isobutyl-L-isoleucinamide and 2.60 g of triethylamine in 400 ml of dichloromethane was stirred at room temperature overnight. The solvent was removed by evaporation and the crude product was chromatographed on silica gel using ethyl acetate for the elution. The resulting product was triturated with a mixture of petroleum ether (b.p. 40°-60° C.) and ethyl acetate to give 8.70 g of N2 -[N-[[N-(benzyloxycarbonyl)-L-phenylalanyl]methyl]-L-prolyl]-N1 -isobutyl-L-isoleucinamide as an off-white solid of m.p. 80°-81° C.

Источник