Реакция #82227

Уравнение реакции

2-acetyl-4-bromophenol

ethyl bromoacetate

potassium carbonate

→

ethyl (2-acetyl-4-bromophenyl)oxyacetate

Выход 90.2%

Растворители

acetone

chloroform

Условия реакции

Обработка

1. 1
   ДругоеInsoluble materials were removed by filtration
2. 2
   Концентрированиеthe resulting filtrate was concentrated
3. 3
   Другоеdried
4. 4
   ДругоеThe residue thus obtained
5. 5
   Промывкаwashed with water
6. 6
   Другоеdried
7. 7
   Другоеto remove the solvent
8. 8
   ПромывкаThe thus treated residue was washed with a mixed solvent system of ethanol and n-hexane
9. 9
   Другоеto isolate insoluble crystals
10. 10
    Фильтрацияby filtration

Методика

13.31 g of 2-acetyl-4-bromophenol, 11.0 g of ethyl bromoacetate and 9.7 g of anhydrous potassium carbonate were refluxed under heating in 70 ml of acetone for 2 hours. Insoluble materials were removed by filtration, and the resulting filtrate was concentrated and dried. The residue thus obtained was dissolved in chloroform, washed with water, and then dried to remove the solvent. The thus treated residue was washed with a mixed solvent system of ethanol and n-hexane to isolate insoluble crystals by filtration. In this way, 16.82 g of ethyl (2-acetyl-4-bromophenyl)oxyacetate was obtained in the form of colorless plate crystals.

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