Реакция #8206

ord-cc06287670bb4fbd823adbb3133bb5b9

Уравнение реакции

CC(C)(Cc1c[nH]c2c(CS(=O)(=O)C(F)(F)F)cccc12)NC(=O)OC(C)(C)C
[1,1-dimethyl-2-(7-trifluoromethanesulfonylmethyl-1H-indol-3-yl)-ethyl]-carbamic acid tert-butyl ester
C=CC#N
acrylonitrile
→
CC(C)(Cc1c[nH]c2c(C=CC#N)cccc12)NC(=O)OC(C)(C)C
{2-[7-(2-Cyano-vinyl)-1H-indol-3-yl]-1,1-dimethyl-ethyl}-carbamic acid tert-butyl ester

Реактанты

CC(C)(Cc1c[nH]c2c(CS(=O)(=O)C(F)(F)F)cccc12)NC(=O)OC(C)(C)C
[1,1-dimethyl-2-(7-trifluoromethanesulfonylmethyl-1H-indol-3-yl)-ethyl]-carbamic acid tert-butyl ester
C=CC#N
acrylonitrile
—
Amine

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

{2-[7-(2-Cyano-vinyl)-1H-indol-3-yl]-1,1-dimethyl-ethyl}-carbamic acid tert-butyl ester is prepared from [1,1-dimethyl-2-(7-trifluoromethanesulfonylmethyl-1H-indol-3-yl)-ethyl]-carbamic acid tert-butyl ester and acrylonitrile as described for the preparation of Amine 23 (85%). FDMS m/e=339.2 (M++1).

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US07087635B2uspto-grants-2006_08