Реакция #816394

Уравнение реакции

phytantriol

acetone

→

2-(2,2-dimethyl-[1,3]dioxolan-4-yl)-6,10,14-trimethyl-pentadecan-2-ol

Условия реакции

Обработка

1. 1
   Другоеfor 15 hr
2. 2
   ДругоеAfter the completion of the reaction
3. 3
   Другоеthe acetone solvent was removed under reduced pressure
4. 4
   Экстракцияthe resultant was extracted with chloroform solution
5. 5
   ПромывкаThe extract was washed with saturated sodium bicarbonate solution
6. 6
   Промывкаwas again washed with saline

Методика

One g of phytantriol (3.0 mmol, Sigma-Aldrich) was refluxed using deanstock apparatus for 15 hr in 25 ml of acetone solution with toluene sulfonic acid as catalyst. After the completion of the reaction, the acetone solvent was removed under reduced pressure and the resultant was extracted with chloroform solution. The extract was washed with saturated sodium bicarbonate solution and was again washed with saline to obtain 0.3 g of (2-(2,2-dimethyl-[1,3]dioxolan-4-yl)-6,10,14-trimethyl-pentadecan-2-ol) of which 1- and 2-positions were protected.

Источник