Реакция #816393

Уравнение реакции

phytandiol

para-toluene sulfonyl phytandiol

sodium azide

azide

→

azido phytandiol

Выход 81.6%

Растворители

dimethyl formamide

Условия реакции

Обработка

1. 1
   Температураby reflux for 5 hr in order
2. 2
   ЭкстракцияThe reaction mixture was extracted with 50 ml of methylene chloride solution
3. 3
   Промывкаwashed with saline
4. 4
   СушкаFollowing drying over anhydrous magnesium sulfate, filtration and concentration

Методика

The yielded phytandiol derivative (0.48 g) was dissolved in 25 ml of dimethyl formamide and 0.06 g (1.00 mmol) of sodium azide (Sigma-Aldrich) was added, followed by reflux for 5 hr in order to substitute azide for para-toluene sulfonyl group. The reaction mixture was extracted with 50 ml of methylene chloride solution and washed with saline. Following drying over anhydrous magnesium sulfate, filtration and concentration, 0.29 g of azido phytandiol derivative was yielded.

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