Реакция #8161

ord-3dfffe55f58b4bbcb2b5d2ddd09a9a2a

Уравнение реакции

NNc1ccc([N+](=O)[O-])cn1
(5-nitropyridin-2-yl)hydrazine
CCOC(=O)C(C(C)=O)C(C)=O
2-acetyl-3-oxo-butyric acid ethyl ester
c1ccncc1
pyridine
→
CCOC(=O)c1c(C)nn(-c2ccc([N+](=O)[O-])cn2)c1C
3,5-dimethyl-1-(5-nitropyridin-2-yl)-1H-pyrazole-4-carboxylic acid ethyl ester

Реактанты

—
product
NNc1ccc([N+](=O)[O-])cn1
(5-nitropyridin-2-yl)hydrazine
CCOC(=O)C(C(C)=O)C(C)=O
2-acetyl-3-oxo-butyric acid ethyl ester
c1ccncc1
pyridine

Реагенты

Нет

Растворители

CCO
ethanol

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

Similar to Example 1, equimolar amounts of (5-nitropyridin-2-yl)hydrazine and 2-acetyl-3-oxo-butyric acid ethyl ester were combined in a solution of 50% pyridine in ethanol. Analysis confirmed synthesis of the named product (m.p. 117° C.–119° C.).

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US07087634B2uspto-grants-2006_08