Реакция #8159

Уравнение реакции

2-pyridylhydrazine

2-acetyl-3-oxo-butyric acid ethyl ester

pyridine

→

3,5-dimethyl-1-pyridin-2-yl-1H-pyrazole-4-carboxylic acid ethyl ester

Растворители

ethanol

Условия реакции

Обработка

1. 1
   Температураheated
2. 2
   Температураunder reflux
3. 3
   ДругоеThe solvents were removed under vacuum
4. 4
   Другоеthe residue purified over silica
5. 5
   ДругоеThe named product crystallized

Методика

Similar to Example 1, 2-pyridylhydrazine (7.5 mmol, 0.8 g) and 2-acetyl-3-oxo-butyric acid ethyl ester (7.5 mmol, 1.3 g) were mixed in a solution of 50% pyridine in ethanol, then heated under reflux. The solvents were removed under vacuum and the residue purified over silica. The named product crystallized upon standing (m.p. 49° C.–50° C.).

Источник