Реакция #8154

Уравнение реакции

m-nitrophenylhydrazine hydrochloride

2-acetyl-3-oxo-butyric acid ethyl ester

pyridine

→

3,5-dimethyl-1-(3-nitrophenyl)-1H-pyrazole-4-carboxylic acid ethyl ester

Растворители

ethanol

Условия реакции

Обработка

1. 1
   ДругоеA precipitate was formed in the reaction medium
2. 2
   Фильтрацияwas collected by filtration
3. 3
   Другоеsynthesis of the named product
4. 4
   Другоеm.p., 107.7° C.–109.2° C.

Методика

Similar to Example 1, m-nitrophenylhydrazine hydrochloride (10 mmol, 1.9 g) and 2-acetyl-3-oxo-butyric acid ethyl ester (10 mmol, 1.7 g) were mixed in a 50% solution of pyridine in ethanol. A precipitate was formed in the reaction medium, and was collected by filtration. Analysis confirmed synthesis of the named product, m.p., 107.7° C.–109.2° C.

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