Реакция #81452

Уравнение реакции

compound

5-benzyl-3,3-dibromo-1-methyl-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one

acetic acid

→

title product

Выход 60.0%

5-benzoyl-1-methyl-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one

Выход 60.0%

Условия реакции

Обработка

1. 1
   Концентрированиеconcentrate to dryness under reduced pressure
2. 2
   Экстракцияextract with dichloromethane
3. 3
   ДругоеThe crude product obtained
4. 4
   Концентрированиеby concentrating to dryness
5. 5
   Другоеis purified by chromatography on a silica column (eluant: petroleum ether/ethyl acetate, 6/4)

Методика

Add a spatula tip of zinc to a solution of 40 mg of the compound of Step 2 in acetic acid. After 30 minutes' stirring, concentrate to dryness under reduced pressure, take up in water and extract with dichloromethane. The crude product obtained by concentrating to dryness is purified by chromatography on a silica column (eluant: petroleum ether/ethyl acetate, 6/4). The title product is obtained in the form of an oil in a yield of 60%. ##STR63##

Источник