Реакция #81377

Уравнение реакции

4-formylphenol

1-bromooctane

potassium carbonate

→

desired compound

4-octyloxybenzaldehyde

Растворители

acetone

Условия реакции

Обработка

1. 1
   Температураwas refluxed overnight
2. 2
   Другоеthe reaction was quenched by the addition of 100 ml of water
3. 3
   ЭкстракцияThe desired compound was extracted from the reaction mixture
4. 4
   СушкаThe resultant solution was dried over magnesium sulfate
5. 5
   Фильтрацияfiltered
6. 6
   Концентрированиеconcentrated in vacuo
7. 7
   Другоеto provide a liquid which
8. 8
   Другоеwas purified

Методика

A solution containing 3.053 g (25 mmol) of 4-formylphenol, 6.48 ml (3705 mmol) of 1-bromooctane and 6.9 mg (50 mmol) of potassium carbonate in 100 ml of acetone was refluxed overnight. When the reaction was substantially complete, as indicated by thin layer chromatagraphy (TLC), the reaction was quenched by the addition of 100 ml of water. The desired compound was extracted from the reaction mixture using two 100 ml portions of diethyl ether. The resultant solution was dried over magnesium sulfate, filtered and then concentrated in vacuo to provide a liquid which was purified using HPLC (eluent of 10 ethyl acetate in hexane) to provide the desired compound.

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