Реакция #80724

Уравнение реакции

4,4-dimethyl-2-oxo-1,2,3,4-tetrahydro-6-[(trimethylsilyl)ethynyl]quinoline

4,4-dimethyl-2-oxo-1,2,3,4-tetrahydro-6[(trimethylsilyl)ethynyl]quinoline

Compound 2

4,4-dimethyl-2-oxo-1,2,3,4-tetrahydro-6[(trimethylsilyl)ethynyl]quinoline

4,4-dimethyl-2-oxo-1,2,3,4-tetrahydro-7-bromoquinoline

Compound 18

4,4-dimethyl-2-oxo-1,2,3,4-tetrahydro-7-bromoquinoline

triethylamine

→

title compound

Выход 74.0%

4,4-Dimethyl-2-oxo-1,2,3,4-tetrahydro-7-[(trimethysilyl)ethynyl]quinoline

Выход 74.0%

Условия реакции

Методика

2.2398 g (8.8 mmol) of 4,4-dimethyl-2-oxo-1,2,3,4-tetrahydro-7-bromoquinoline (Compound 18), 371 mg (1.9 mmol) of CuI, 1.087 g (1.5 mmol) of Pd(PPh3)2Cl2, 35 ml (0.251 mol) of triethylamine and 4.0 ml (28.0 mmol) of trimethylacetylene were reacted substantially in accordance with the procedure used for the preparation of 4,4-dimethyl-2-oxo-1,2,3,4-tetrahydro-6-[(trimethylsilyl)ethynyl]quinoline (Compound 2) to give the title compound as pale orange solids (74%).

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