Реакция #806809

Уравнение реакции

2-chloro-5-formyl-N-(tricyclo [3.3.1.13,7]dec-1-ylmethyl)-benzamide

2-(2-aminoethylthio)ethanol

sodium triacetoxyborohydride

→

title compound

Выход 50.9%

2-Chloro-5-[[2-(2-hydroxyethylthio)ethylamino]methyl]-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-benzamide

Выход 50.9%

Растворители

1,2-dichloroethane

Условия реакции

Обработка

1. 1
   ДругоеPrepared
2. 2
   ДругоеAfter work-up, the residue was purified by NPHPLC
3. 3
   Промывкаeluting with a gradient of 0–10% ethanol in dichloromethane

Методика

Prepared according to the method described in Example 2 from 2-chloro-5-formyl-N-(tricyclo [3.3.1.13,7]dec-1-ylmethyl)-benzamide (0.800 g, Example 1b), 2-(2-aminoethylthio)ethanol (0.584 g) and sodium triacetoxyborohydride (0.715 g) in 1,2-dichloroethane (15 ml). After work-up, the residue was purified by NPHPLC eluting with a gradient of 0–10% ethanol in dichloromethane to give the title compound as a white powder (0.536 g).

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