Реакция #806576

Уравнение реакции

4-vinylphenol

4-Chloromethyl-2-methylquinoline

Cs2CO3

NaI

→

2-methyl-4-(4-vinyl-phenoxymethyl)-quinoline

Выход 46.8%

Растворители

DMSO

Условия реакции

Обработка

1. 1
   ДругоеAfter work up, the residue was purified by flash column chromatography (40% ethyl acetate-hexanes)

Методика

A mixture of 4-vinylphenol (10% wt. solution in propylene glycol) (1.25 g, 1.04 mmol), 4-Chloromethyl-2-methylquinoline (0.24 g, 1.2 eq), Cs2CO3 (0.85 g, 2.5 eq) and NaI (0.20 g, 1.2 eq) in DMSO (1 ml) was stirred at rt overnight. After work up, the residue was purified by flash column chromatography (40% ethyl acetate-hexanes) to give 2-methyl-4-(4-vinyl-phenoxymethyl)-quinoline (0.134 g, 46.8%) as a white solid. MS Found: (M+H)+=276.

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