Реакция #80271

Уравнение реакции

water

4-formyl-5-hydroxy-3-methylbenzothiophene

4,6-dimethoxy-2-methylsulfonylpyrimidine

potassium carbonate

→

desired compound

Выход 86.0%

5-(4,6-dimethoxypyrimidin-2-yl)oxy-4-formyl-3-methylbenzothiophene

Выход 86.0%

Растворители

N,N-dimethylformamide

Условия реакции

Обработка

1. 1
   Температураwas heated
2. 2
   Другоеwas returned to room temperature
3. 3
   Экстракцияextracted with ethyl acetate
4. 4
   ПромывкаThe organic layer was washed with water
5. 5
   Сушкаdried over anhydrous sodium sulfate
6. 6
   КонцентрированиеThen, it was concentrated under reduced pressure
7. 7
   Другоеthe oily substance thereby obtained
8. 8
   Другоеwas purified by silica gel column chromatography (n-hexane/ethyl acetate=10/1)

Методика

A mixture comprising 2.1 g of 4-formyl-5-hydroxy-3-methylbenzothiophene, 2.4 g of 4,6-dimethoxy-2-methylsulfonylpyrimidine and 1.8 g of potassium carbonate in 30 ml of N,N-dimethylformamide, was heated and stirred at 70° C. for 3 hours. The mixture was returned to room temperature, then poured into water and extracted with ethyl acetate. The organic layer was washed with water and then dried over anhydrous sodium sulfate. Then, it was concentrated under reduced pressure, and the oily substance thereby obtained was purified by silica gel column chromatography (n-hexane/ethyl acetate=10/1) to obtain 3.1 g (yield: 86%) of the desired compound.

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