Реакция #79931

ord-26881a7d141d4d76959391f5a3e6dc3c

Уравнение реакции

O=C([O-])[O-].[K+].[K+]
potassium carbonate
CC(C)N(C)C1CCC(C)(C)c2cc(C#C[Si](C)(C)C)ccc21
1-(methyl-iso-propylamino)-4,4-dimethyl-6-trimethylsilanylethynyl-1,2,3,4-tetrahydro-naphthalene
CC(C)N(C)C1CCC(C)(C)c2cc(C#C[Si](C)(C)C)ccc21
Intermediate 28
CC(C)N(C)C1CCC(C)(C)c2cc(C#C[Si](C)(C)C)ccc21
1-(methyl-iso-propylamino)-4,4-dimethyl-6-trimethylsilanylethynyl-1,2,3,4-tetrahydro-naphthalene
CO
methanol
→
C#Cc1ccc2c(c1)C(C)(C)CCC2N(C)C(C)C
title compound
Выход 80.0%
C#Cc1ccc2c(c1)C(C)(C)CCC2N(C)C(C)C
6-Ethynyl-1-(iso-propyl-methyl-amino)-4,4-dimethyl-1,2,3,4-tetrahydro-naphthalene
Выход 80.0%

Реактанты

O=C([O-])[O-].[K+].[K+]
potassium carbonate
CC(C)N(C)C1CCC(C)(C)c2cc(C#C[Si](C)(C)C)ccc21
1-(methyl-iso-propylamino)-4,4-dimethyl-6-trimethylsilanylethynyl-1,2,3,4-tetrahydro-naphthalene
CC(C)N(C)C1CCC(C)(C)c2cc(C#C[Si](C)(C)C)ccc21
Intermediate 28
CC(C)N(C)C1CCC(C)(C)c2cc(C#C[Si](C)(C)C)ccc21
1-(methyl-iso-propylamino)-4,4-dimethyl-6-trimethylsilanylethynyl-1,2,3,4-tetrahydro-naphthalene
CO
methanol

Реагенты

Нет

Растворители

CCOC(C)=O
ethyl acetate

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

Following general procedure E and using 1-(methyl-iso-propylamino)-4,4-dimethyl-6-trimethylsilanylethynyl-1,2,3,4-tetrahydro-naphthalene (Intermediate 28, 0.14 g, 0.45 mmol), methanol (5 mL), potassium carbonate (0.61 g, 4.41 mmol) and ethyl acetate the title compound (0.092 g, 80%) was obtained as an oil.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US06713647B2uspto-grants-2004_03