Реакция #79763

Уравнение реакции

2-fluorobenzonitrile

4-bromophenol

potassium carbonate

→

2-(4-bromophenoxy)benzonitrile

Растворители

dimethylformamide

Условия реакции

Обработка

1. 1
   Температураwas heated
2. 2
   workup.WAITto stand overnight at ambient temperature
3. 3
   Другоеpartitioned between ethyl acetate and water
4. 4
   ДругоеThe organic layer was separated
5. 5
   Промывкаwashed
6. 6
   Другоеdried
7. 7
   Другоеevaporated
8. 8
   Другоеto give an oil which
9. 9
   ДругоеThe solid was triturated with petroleum ether b.p. 40-60° C.
10. 10
    Фильтрацияfiltered

Методика

A mixture of 2-fluorobenzonitrile (28.8 g), 4-bromophenol (36.9 g), potassium carbonate (58.9 g) and dimethylformamide (30 ml) was heated with stirring under nitrogen at 120° C. for 5 hours. The mixture was allowed to stand overnight at ambient temperature and then partitioned between ethyl acetate and water. The organic layer was separated, washed, dried and evaporated to give an oil which solidified on standing. The solid was triturated with petroleum ether b.p. 40-60° C. and filtered to give 2-(4-bromophenoxy)benzonitrile.

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