Реакция #79578

Уравнение реакции

Sodium triacetoxyborohydride

Acetic acid

p-anisaldehyde

ethanolamine

→

title compound

2-[(4-Methoxybenzyl)amino]ethanol

Растворители

methanol

Условия реакции

Обработка

1. 1
   workup.ADDITIONonce addition
2. 2
   КонцентрированиеThe mixture was concentrated under reduced pressure
3. 3
   Экстракцияextracted with dichloromethane (10×300 ml)
4. 4
   ДругоеThe combined extracts were evaporated
5. 5
   Другоеthe crude product was purified by column chromatography on silica gel using an elution gradient of dichloromethane:methanol (98:2 to 90:10)

Методика

Acetic acid (ca. 150 ml) was added to a solution of p-anisaldehyde (58.2 g, 0.42 mol) and ethanolamine (152 ml, 2.52 mol) in methanol (1L), to achieve a pH of 6. Sodium triacetoxyborohydride (100 g, 0.47 mol) was added portionwise, and once addition was complete, the mixture was stirred at room temperature for 72 hours. The mixture was concentrated under reduced pressure, basified using 1N sodium hydroxide solution and extracted with dichloromethane (10×300 ml). The combined extracts were evaporated and the crude product was purified by column chromatography on silica gel using an elution gradient of dichloromethane:methanol (98:2 to 90:10) to afford the title compound, 42 g. 1H-NMR (CDCl3, 400 MHz) δ: 2.78 (t, 2H), 3.62 (t, 2H), 3.75 (m, 5H), 4.24 (s, 2H), 6.81 (d, 2H), 7.22 (d, 2H). LRMS: m/z (ES+) 182 [MH+].

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