Реакция #79569

Уравнение реакции

N-cyclohexylaniline

benzyl isothiocyanate

→

(cyclohexylphenylamino)-N-benzylthiocarboxamide

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   ДругоеThe solvent was removed under reduced pressure
2. 2
   Другоеthe residue purified on preparative silica gel plates

Методика

To a solution of N-cyclohexylaniline (0.1 ml, 0.57 mmol) in acetonitrile (4 ml) was added a catalytic amount of 4-(dimethylamino)pyridine (5 mg, 0.04 mmol). To this mixture was added benzyl isothiocyanate (0.11 ml, 0.83 mmol) dropwise, and the mixture was stirred at room temperature for 16 hours. The solvent was removed under reduced pressure, and the residue purified on preparative silica gel plates, developing with 20% ethyl acetate/hexanes, to furnish (cyclohexylphenylamino)-N-benzylthiocarboxamide as a white solid, (M+1)=324.8.

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