Реакция #795509

Уравнение реакции

2-bromo-N-(prop-2-yn-1-yl)acetamide

N-methyl piperazine

→

title compound

Выход 49.0%

2-(4-methylpiperazin-1-yl)-N-(prop-2-yn-1-yl)acetamide

Выход 49.0%

Растворители

DCM

DCM

Условия реакции

Обработка

1. 1
   ДругоеReaction mixture
2. 2
   Промывкаwashed with water and brine
3. 3
   СушкаThe organic layer was dried over Na2SO4
4. 4
   Концентрированиеconcentrated in vacuo
5. 5
   ДругоеThe crude residue was triturated with ether-pentane

Методика

To a solution of 2-bromo-N-(prop-2-yn-1-yl)acetamide (0.7 g, 3.98 mmol) in DCM (10 mL) added N-methyl piperazine (0.66 mL, 5.96 mmol) drop wise. Reaction mixture stirred at rt for 16 h, diluted with DCM and washed with water and brine. The organic layer was dried over Na2SO4 and concentrated in vacuo. The crude residue was triturated with ether-pentane, affording the title compound (0.38 g, 49%); LCMS: m/z=196.15 (M+1); 1H NMR (300 MHz, DMSO-d6) δ 8.06 (d, J=6.1 Hz, 1H), 3.86 (dd, J=5.9, 2.5 Hz, 2H), 3.07 (t, J=2.5 Hz, 1H), 2.91 (s, 2H), 2.47-2.25 (m, 8H), 2.15 (s, 3H).

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