Реакция #792145

Уравнение реакции

(E)-1-(2-hydroxy-4-isobutoxyphenyl)-3-(pyridin-2-yl)prop-2-en-1-one

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final compound

Выход 84.7%

1-(2-hydroxy-4-isobutoxyphenyl)-3-(pyridine-2-yl)propan-1-one

Выход 84.7%

Растворители

EtOAc

Условия реакции

Обработка

1. 1
   Другоеwas conducted at atmospheric pressure room temperature until the starting material
2. 2
   ФильтрацияThe catalyst was filtered
3. 3
   Другоеthe crude was purified by chromatography on silica gel (25% EtOAc/hexane)

Методика

In a 200 mL round-bottomed flask, (E)-1-(2-hydroxy-4-isobutoxyphenyl)-3-(pyridin-2-yl)prop-2-en-1-one (1.08 g, 3.63 mmol) and 80 mg of 10% Pd/C was mixed together in wet EtOAc (50 ml). Hydrogenation was conducted at atmospheric pressure room temperature until the starting material was gone. The catalyst was filtered and the crude was purified by chromatography on silica gel (25% EtOAc/hexane) to provide 0.92 g of final compound (82%) as off white solid.

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