Реакция #792140

Уравнение реакции

sodium hydroxide

triazole

2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-ethyl-oxirane

N-methyl-2-pyrrolidon

ammonium chloride

→

2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1-(1,2,4-triazol-1-yl)butan-2-ol

Условия реакции

Обработка

1. 1
   Экстракцияthe mixture extracted with MTBE
2. 2
   Промывкаwashed with an aqueous solution of lithium chloride
3. 3
   ДругоеThe crude residue was purified by recrystallization in diisopropylether

Методика

To 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-ethyl-oxirane (216.0 g, 0.63 mol) dissolved in N-methyl-2-pyrrolidon (2 L) was added sodium hydroxide (62.87 g, 1.57 mol) and triazole (217.1 g, 3.14 mol) at room temperature. The mixture was then stirred for 12 hours at 140° C. A solution of ammonium chloride and ice water was then added, the mixture extracted with MTBE and washed with an aqueous solution of lithium chloride. The crude residue was purified by recrystallization in diisopropylether to give 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1-(1,2,4-triazol-1-yl)butan-2-ol compound as a colorless solid (127.0 g, 51%; m.p.=140-142° C.).

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