Реакция #79164

Уравнение реакции

hydrogen chloride

N-(2-pyridyl)-o-phenylenediamine

(E)-2,4-difluorocinnamoyl chloride

(E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole

→

titled compound

(E)-2-(2.4-Difluorostyryl)-1-(2-pyridyl)-1H-benzimidazole hydrochloride

Растворители

methanol

Условия реакции

Обработка

1. 1
   Другоеobtained as
2. 2
   КонцентрированиеConcentration and recrystallization from ethyl acetate/ethanol

Методика

To a solution of (E)-2,4-difluorocinnamic acid (331 mg, 1.8 mmol) in benzene (10 ml) was added thionyl chloride (0.5 ml) and the mixture was heated to reflux for 60 min. Volatiles were removed by evaporation to give crude (E)-2,4-difluorocinnamoyl chloride. Free base of the titled compound was prepared from N-(2-pyridyl)-o-phenylenediamine (250 mg, 1.4 mmol) and (E)-2,4-difluorocinnamoyl chloride obtained as above according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method A). The free base was dissolved with a 10% methanol solution of hydrogen chloride (5 ml). Concentration and recrystallization from ethyl acetate/ethanol yielded the titled compound. MW: 369.80; mp: 194.8-196.8° C.; 1H-NMR (DMSO) δ: 8.84-8.79 (1H, m), 8.30-8.08 (2H, m), 7.96-7.82 (3H, m), 7.78-7.69 (1H, m), 7.61-7.13 (6H, m).

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