Реакция #7916

Уравнение реакции

Pyrrolidine

acetic acid

5-methoxy-2-methyl-2-(3-oxo-butyl)-1-indanone

→

7-methoxy-9a-methyl-1,2,9,9a-tetrahydro-3H-fluoren-3-one

Выход 99.1%

Растворители

toluene

EtOAc

Условия реакции

Обработка

1. 1
   ТемператураAfter cooling to room temperature
2. 2
   Промывкаwashed with water (20 mL), 5% NaHCO3 (20 mL), and brine (10 mL)
3. 3
   Сушкаdried over MgSO4
4. 4
   Фильтрацияfiltered
5. 5
   Другоеevaporated under vacuum

Методика

Pyrrolidine (0.159 mL, 1.9 mmol) and acetic acid (0.109 mL, 1.9 mmol) were added to a solution of 5-methoxy-2-methyl-2-(3-oxo-butyl)-1-indanone (467 mg, 1.9 mmol) in toluene (5 mL) and the resulting solution was heated in an oil bath at 85° C. for 2.5 hours. After cooling to room temperature, the reaction mixture was diluted with EtOAc (20 mL), washed with water (20 mL), 5% NaHCO3 (20 mL), and brine (10 mL), dried over MgSO4, filtered, and evaporated under vacuum to yield 7-methoxy-9a-methyl-1,2,9,9a-tetrahydro-3H-fluoren-3-one (430 mg) as a light brown solid.

Источник