Реакция #79046

Уравнение реакции

6-chloro-3-nitropicolinonitrile

H2SO4

→

6-chloro-3-nitropicolinamide

Выход 73.0%

Условия реакции

Обработка

1. 1
   ЭкстракцияThe mixture is extracted four times with EtOAc

Методика

A solution of 6-chloro-3-nitropicolinonitrile (1.00 g, 5.45 mmol) in 90% H2SO4 (15 mL) is warmed at 70° C. for 3.5 h, and then poured into ice-water. The mixture is extracted four times with EtOAc and the combined extracts worked up to give 6-chloro-3-nitropicolinamide (0.80 g, 73%). 1H NMR (DMSO) δ 8.55 (1H, d, J=8.5 Hz), 8.31, 8.04 (1H, 1H, 2 brs), 7.93 (1H, d, J=8.5 Hz).

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