Реакция #78145

Уравнение реакции

potassium carbonate

1-chloro-4-(4-pyridylmethyl)phthalazine

4-fluoroaniline

acetate

→

Title compound

1-(4-Fluoroanilino)-4-(4-pyridylmethyl)phthalazine

Условия реакции

Обработка

1. 1
   ПромывкаThe organic phase washed with water
2. 2
   Сушкаdried over sodium sulfate
3. 3
   Другоеis evaporated
4. 4
   Другоеthe residue purified on silica gel by flash chromatography

Методика

A mixture of 0.511 g (2 mmol) 1-chloro-4-(4-pyridylmethyl)phthalazine and 0.576 ml (6 mmol) 4-fluoroaniline is heated for 2 h at 90° C. The residue is then distributed between acetate and 20% aqueous potassium carbonate solution. The organic phase washed with water and dried over sodium sulfate is evaporated and the residue purified on silica gel by flash chromatography using acetate/methanol mixtures (50:1 and 25:1). Title compound is obtained after crystallization of the product-containing fractions from acetonitrile and drying under HV (6 h, 100° C.); m.p. 129-131° C.; ESI-MS: (M+H)+=331.

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