Реакция #78078

Уравнение реакции

water

5-bromo-2,4-dichloropyrimidine

4-methoxyphenol

potassium carbonate

→

product

Выход 96.0%

5-Bromo-2-chloro-4-(4-methoxyphenoxy)pyrimidine

Выход 96.0%

Растворители

DMF

Условия реакции

Обработка

1. 1
   Другоеthe solid which separated out
2. 2
   Фильтрацияwas collected by filtration
3. 3
   Промывкаwashed with water (50 ml)
4. 4
   Другоеdried under high vacuum

Методика

A mixture of 5-bromo-2,4-dichloropyrimidine (5.0 g, 22.0 mmol), 4-methoxyphenol (2.72 g, 22.0 mmol) and potassium carbonate (6.07 g, 44.0 mmol) in DMF (20 ml) was stirred for 24 hours. The mixture was added to water (100 ml) and the solid which separated out was collected by filtration, washed with water (50 ml) and dried under high vacuum to give the product (6.6 g, 96%). NMR: 3.8 (s, 3H), 7.0 (d, 2H), 7.2 (d, 2H), 8.8 (s, 11H).

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