Реакция #77799

ord-ab6c5940e3a94eada80f6cb34f230bc5

Уравнение реакции

Cc1ccc(S(=O)(=O)N2CCc3cc(C#CCCCO)c(F)cc32)cc1
5-[6-Fluoro-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indol-5-yl]-pent-4-yn-1-ol
CCNCCO
2-(ethylamino)ethanol
→
CCN(CCO)CCCC#Cc1cc2c(cc1F)N(S(=O)(=O)c1ccc(C)cc1)CC2
2-(Ethyl-{5-[6-fluoro-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indol-5-yl]-pent-4-ynyl}-amino)-ethanol

Реактанты

Cc1ccc(S(=O)(=O)N2CCc3cc(C#CCCCO)c(F)cc32)cc1
5-[6-Fluoro-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indol-5-yl]-pent-4-yn-1-ol
CCNCCO
2-(ethylamino)ethanol

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

In analogy to example 16.13, 5-[6-Fluoro-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indol-5-yl]-pent-4-yn-1-ol and 2-(ethylamino)ethanol instead of 2-(methylamino)ethanol were converted to yield 2-(Ethyl-{5-[6-fluoro-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indol-5-yl]-pent-4-ynyl}-amino)-ethanol as a light yellow oil, MS: 445 (MH+).

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US06706751B2uspto-grants-2004_03