Реакция #77419

Уравнение реакции

bromine

2-[(6-bromo-2-pyridinyl)amino]thiazole

→

titled compound

Выход 94.0%

6-Bromo-N-(5-bromo-2-thiazolyl)pyridin-2-amine

Выход 94.0%

Растворители

acetic acid

acetic acid

potassium hydrogen sulfate

Условия реакции

Обработка

1. 1
   workup.ADDITIONAfter addition
2. 2
   workup.STIRRINGstirred for several min
3. 3
   ФильтрацияThe precipitated solid was filtered
4. 4
   Промывкаwashed several times with water
5. 5
   Сушкаdried in vacuo over P2O5

Методика

A solution of bromine (1.1 mL, 20.9 mmol) in acetic acid (15 mL) was added dropwise to a solution of 2-[(6-bromo-2-pyridinyl)amino]thiazole (2.68 g, 10.46 mmol) in acetic acid (23 mL) at 40° C. After addition, the mixture was stirred at rt. for 3 h. The mixture was diluted with aqueous potassium hydrogen sulfate solution (60 mL) at 0° C. and stirred for several min. The precipitated solid was filtered, washed several times with water and dried in vacuo over P2O5 to obtain the titled compound (3.28 g, 94%) as an off-white solid.

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