Реакция #77296

Уравнение реакции

NaOH

2,5-difluoroaniline

bis(2-chloroethyl)amine hydrochloride

sodium carbonate

→

title compound

Выход 15.5%

(2,5-Difluorophenyl)piperazine

Выход 15.5%

Растворители

hexane

butanol

Условия реакции

Обработка

1. 1
   Температураwas heated
2. 2
   Температураat reflux for 24 hours
3. 3
   Температураthe mixture was heated again
4. 4
   Температураat reflux
5. 5
   Температураthe mixture was cooled to room temperature
6. 6
   Другоеthe resulting layers were separated
7. 7
   ЭкстракцияThe aqueous layer was extracted with chloroform (3×25 mL)
8. 8
   ПромывкаThe silica gel was further eluted with a gradient of chloroform to chloroform/methanol (4:1)
9. 9
   ДругоеThe solvent was removed from the combined fractions with Rf=0.14 [silica gel, chloroform/methanol (4:1)]

Методика

A mixture of 2,5-difluoroaniline (2.58 g, 20 mmol) and bis(2-chloroethyl)amine hydrochloride (3.96 g, 22 mmol) in butanol (10 mL) was heated at reflux for 24 hours. The mixture was cooled to room temperature, sodium carbonate (2.33 g, 22 mmol) was added, and the mixture was heated again at reflux. After 2 days, the mixture was cooled to room temperature, hexane (15 mL) and 3 N NaOH (25 mL) were added, and the resulting layers were separated. The aqueous layer was extracted with chloroform (3×25 mL) and the combined organic fractions were flashed over a column of silica gel. The silica gel was further eluted with a gradient of chloroform to chloroform/methanol (4:1). The solvent was removed from the combined fractions with Rf=0.14 [silica gel, chloroform/methanol (4:1)], giving the title compound as a yellow oil (0.606 g, 3.1 mmol, 15%). ESI-MS m/z 199 (MH+).

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