Реакция #77254

Уравнение реакции

4-amino-5-fluoro-2-(3-methylpicolinoyl)phenyl thiocyanate

ammonium hydroxide

→

title compound

Выход 66.6%

5-Amino-6-fluoro-3-(3-methyl-2-pyridyl)-1,2-benzisothiazole

Выход 66.6%

Растворители

methanol

Условия реакции

Обработка

1. 1
   ДругоеThe methanol is removed in vacuo
2. 2
   Фильтрацияthe resultant mixture is filtered

Методика

A mixture of 4-amino-5-fluoro-2-(3-methylpicolinoyl)phenyl thiocyanate(3.06 g, 0.0112 mole), concentrated ammonium hydroxide (300 ml) and methanol (300 ml) is stirred overnight at room temperature. The methanol is removed in vacuo and the resultant mixture is filtered to afford the title compound as a green solid (1.93 g, 66.6%) which is identified by NMR spectral analysis.

Источник