Реакция #7714

Уравнение реакции

sodium iodide

4,6-dichloro-2-methylsulfanyl-pyrimidine

3-amino-5-methylpyrazole

diisopropylethylamine

→

[6-chloro-2-methylsulfanyl-pyrimidin-4-yl)-(5-methyl-2H-pyrazol-3-yl)-amine

Растворители

BuOH

Условия реакции

Обработка

1. 1
   ДругоеThe solvent is then removed in vacuo
2. 2
   Другоеthe residue is purified by flash chromatography (SiO2, hexane/AcOEt gradient)

Методика

To a solution of 4,6-dichloro-2-methylsulfanyl-pyrimidine (5 g, 25.6 mmol) and 3-amino-5-methylpyrazole 2.61 g, 26.9 mmol) in BuOH (60 mL) is added diisopropylethylamine (4.69 mL, 26.9 mmol) followed by sodium iodide (3.84 g, 25.6 mmol). The reaction mixture is stirred for 15 hours at 120° C. The solvent is then removed in vacuo and the residue is purified by flash chromatography (SiO2, hexane/AcOEt gradient) to give [6-chloro-2-methylsulfanyl-pyrimidin-4-yl)-(5-methyl-2H-pyrazol-3-yl)-amine.

Источник