Реакция #77127

ord-fad09eb0b6c7469280ba68a71128044d

Уравнение реакции

COc1ccc(CC2c3cc(OC)c(OC)cc3CCN2CC(=O)NCc2ccccc2)cc1O
2-[1-(3-hydroxy-4-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide
FCCCBr
1-bromo-3-fluoro-propane
→
COc1cc2c(cc1OC)C(Cc1ccc(OC)c(OCCCF)c1)N(CC(=O)NCc1ccccc1)CC2
2-{1-[3-(3-fluoro-propoxy)-4-methoxy-benzyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl}-N-benzyl-acetamide

Реактанты

COc1ccc(CC2c3cc(OC)c(OC)cc3CCN2CC(=O)NCc2ccccc2)cc1O
2-[1-(3-hydroxy-4-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide
FCCCBr
1-bromo-3-fluoro-propane

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

prepared by reaction of 2-[1-(3-hydroxy-4-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with 1-bromo-3-fluoro-propane

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US06703392B2uspto-grants-2004_03