Реакция #77072

ord-75583557da834f3d824714b83a576cfd

Уравнение реакции

COc1cc2c(cc1O)CCN(CC(=O)NCc1ccccc1)C2Cc1ccc(OC)c(OC)c1
2-[1-(3,4-dimethoxy-benzyl)-6-hydroxy-7-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide
FCCCBr
1-bromo-3-fluoro-propane
→
COc1ccc(CC2c3cc(OC)c(OCCCF)cc3CCN2CC(=O)NCc2ccccc2)cc1OC
2-[1-(3,4-dimethoxy-benzyl)-6-(3-fluoro-propoxy)-7-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide

Реактанты

COc1cc2c(cc1O)CCN(CC(=O)NCc1ccccc1)C2Cc1ccc(OC)c(OC)c1
2-[1-(3,4-dimethoxy-benzyl)-6-hydroxy-7-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide
FCCCBr
1-bromo-3-fluoro-propane

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-6-hydroxy-7-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with 1-bromo-3-fluoro-propane

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US06703392B2uspto-grants-2004_03