Реакция #7707

Уравнение реакции

[2-(4-Acetamido-phenylsulfanyl)-7-nitroquinazolin-4-yl]-(5-methyl-2H-pyrazol-3-yl)-amine

→

[2-(4-acetamido-phenylsulfanyl)-7-aminoquinazolin-4-yl]-(5-methyl-2H-pyrazol-3-yl)-amine

Растворители

EtOH water AcOH

Условия реакции

Обработка

1. 1
   Температураcooled to room temperature
2. 2
   Фильтрацияfiltered through a pad of celite
3. 3
   ПромывкаThe pad is washed with methanol
4. 4
   Концентрированиеthe combined filtrate is concentrated in vacuo
5. 5
   ДругоеThe residue is purified by flash chromatography (SiO2, DCM/MeOH gradient)

Методика

[2-(4-Acetamido-phenylsulfanyl)-7-nitroquinazolin-4-yl]-(5-methyl-2H-pyrazol-3-yl)-amine (182 mg, 4.18.10−4 mol) is dissolved in a mixture EtOH/water/AcOH(25/10/1, 36 mL) and the reaction is heated at 90° C. Iron powder (93 mg) is added and the mixture is stirred at 90° C. for 4 hours, cooled to room temperature and filtered through a pad of celite. The pad is washed with methanol and the combined filtrate is concentrated in vacuo. The residue is purified by flash chromatography (SiO2, DCM/MeOH gradient) to give the desired [2-(4-acetamido-phenylsulfanyl)-7-aminoquinazolin-4-yl]-(5-methyl-2H-pyrazol-3-yl)-amine.

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