Реакция #7694

Уравнение реакции

chloroacetonitrile

benzylpiperazine

→

N-benzyl-N′-cyanomethylpiperazine

Растворители

THF

Et3N

Условия реакции

Обработка

1. 1
   Другоеbefore quenched with saturated aqueous NaHCO3 (100 ml)
2. 2
   ЭкстракцияThe aqueous phase was extracted with EtOAc (3×100 ml)
3. 3
   СушкаThe combined organic layer was dried over MgSO4
4. 4
   Концентрированиеconcentrated to a residue, which
5. 5
   Другоеwas used in the further reactions without any purification

Методика

An excess of chloroacetonitrile (7 ml) was added in to a solution of benzylpiperazine (2 g, 10.5 mmol) in THF (100 ml) and Et3N (10 ml). The reaction was stirred for 10 hours before quenched with saturated aqueous NaHCO3 (100 ml). The aqueous phase was extracted with EtOAc (3×100 ml). The combined organic layer was dried over MgSO4 and concentrated to a residue, which was used in the further reactions without any purification.

Источник