Реакция #76933

ord-cd34c1c5c16745dc9d95365778066982

Уравнение реакции

COc1ccc(CC2NCCc3c(OC)ccc(OC)c32)cc1OC
1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-1,2,3,4,-tetrahydroisoquinoline
O=C(Br)CBr
2-bromoacetyl bromide
NCc1ccccc1
benzylamine
→
COc1ccc(CC2c3c(OC)ccc(OC)c3CCN2CC(=O)NCc2ccccc2)cc1OC
2-[1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide

Реактанты

COc1ccc(CC2NCCc3c(OC)ccc(OC)c32)cc1OC
1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-1,2,3,4,-tetrahydroisoquinoline
O=C(Br)CBr
2-bromoacetyl bromide
NCc1ccccc1
benzylamine

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-1,2,3,4,-tetrahydroisoquinoline and 2-bromoacetyl bromide with benzylamine

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US06703392B2uspto-grants-2004_03