Реакция #7689

Уравнение реакции

4-fluorocinnamic acid

(S)-1-[3-(4-pyridin-2-yl-piperazin-1-yl)phenyl]ethylamine

EDC

triethylamine

→

title compound

Выход 60.4%

(S)-3-(4-Fluorophenyl)-N-{1-[3-(4-pyridin-2-ylpiperazin-1-yl)phenyl]ethyl}-acrylamide

Выход 60.4%

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   ДругоеThe reaction mixture was purified by flash chromatography over silica gel with ethyl acetate/hexanes (1:1)

Методика

A solution of 4-fluorocinnamic acid (17 mg, 0.1 mmol), (S)-1-[3-(4-pyridin-2-yl-piperazin-1-yl)phenyl]ethylamine (24 mg, 0.11 mmol), EDC (28 mg, 0.15 mmol), DMAP (12 mg, 0.1 mmol) and triethylamine (40 mg, 0.4 mmol) in dichloromethane (2 ml) was stirred at room temperature for 14 h. The reaction mixture was purified by flash chromatography over silica gel with ethyl acetate/hexanes (1:1) to give the title compound as a solid (26 mg, 60% yield).

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