Реакция #76838

Уравнение реакции

trifluoroacetic acid

(R)-9-[2-(N-Boc-L-valyloxymethyl)-4-(stearoyloxy)butyl]guanine

→

trifluoracetate

title compound

(R)-9-[2-(L-Valyloxymethyl)-4-(stearoyloxy)butyl]guanine

Условия реакции

Обработка

1. 1
   Другоеevaporated to a small volume
2. 2
   Другоеwas obtained

Методика

Chilled trifluoroacetic acid (2.0 g) was added to (R)-9-[2-(N-Boc-L-valyloxymethyl)-4-(stearoyloxy)butyl]guanine (180 mg; 0.25 mmol) and the solution kept at room temperature for 1 h, evaporated to a small volume, and lyophilized repeatedly with dioxane until a white amorphous powder was obtained. The yield of title compound, obtained as the trifluoracetate salt, was quantitative.

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