Реакция #76711

Уравнение реакции

N-benzyl-2-amino-5-indan carboxamide hydrochloride

triethylamine

4-chloro-5-methylthieno[2,3-d]pyrimidine

→

title compound

Выход 63.6%

N-Benzyl-2-(5-methylthieno[2,3-d]pyrimidine-4-yl)amino-5-indan Carboxamide

Выход 63.6%

Растворители

ethanol

Условия реакции

Обработка

1. 1
   ДругоеA solid obtained
2. 2
   Другоеby purifying the product by silica gel chromatography (methylene chloride:ethanol=95:5)
3. 3
   Промывкаwas washed with ether

Методика

Using N-benzyl-2-amino-5-indan carboxamide hydrochloride (660 mg, 2.2 mmol), ethanol (19 ml), triethylamine (0.94 ml, 6.7 mmol), and 4-chloro-5-methylthieno[2,3-d]pyrimidine (410 mg, 2.2 mmol), a similar procedure to b) in Production Example 208 was carried out. A solid obtained by purifying the product by silica gel chromatography (methylene chloride:ethanol=95:5) was washed with ether to obtain the title compound (580 mg, 1.4 mmol) having the following physical properties:

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