Реакция #76695

Уравнение реакции

triethylamine

4-hydroxy-5,6-dimethylthieno[2,3-d]pyrimidine

phosphorus oxychloride

2-aminoindan

→

title compound

Выход 64.0%

4-(2-Indanylamino)-5,6-dimethylthieno[2,3-d]pyrimidine

Выход 64.0%

Растворители

ethanol

Условия реакции

Обработка

1. 1
   ДругоеThe product obtained
2. 2
   Другоеwas purified by silica gel chromatography (hexane:ethyl acetate=2:1)

Методика

Using 4-hydroxy-5,6-dimethylthieno[2,3-d]pyrimidine (180 mg, 1.0 mmol), phosphorus oxychloride (1.0 ml), 2-aminoindan (270 mg, 2.0 mmol), triethylamine (0.84 ml, 6.0 mmol) and dry ethanol (5 ml), a similar procedure to b) in Production Example 208 was carried out. The product obtained was purified by silica gel chromatography (hexane:ethyl acetate=2:1) to obtain the title compound (190 mg, 0.64 mmol) having the following physical properties:

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