Реакция #76685

Уравнение реакции

4-cyano-5-ethoxymethyleneamino-3-aminoisoxazole

2-aminoindan

ethanol

→

title compound

3-Methyl-4-(2-indanylamino)isoxazolo[5,4-d]pyrimidine

Условия реакции

Обработка

1. 1
   Температураto reflux for 1.5 hours
2. 2
   ДругоеThe residue obtained
3. 3
   workup.DISTILLATIONby distilling off the solvent under reduced pressure
4. 4
   Другоеwas purified by silica gel chromatography (hexane:ethyl acetate=2:1)
5. 5
   ДругоеThe product obtained
6. 6
   Другоеwas crystallized from ethanol

Методика

4-cyano-5-ethoxymethyleneamino-3-aminoisoxazole (320 mg, 1.8 mmol) (see J. Org. Chem., 29, 2116 (1964)) and 2-aminoindan (710 mg, 5.3 mmol) in dry ethanol (3 ml) were heated to reflux for 1.5 hours. The residue obtained by distilling off the solvent under reduced pressure was purified by silica gel chromatography (hexane:ethyl acetate=2:1). The product obtained was crystallized from ethanol to obtain the title compound (270 mg, 0.38 mmol) having the following physical properties:

Источник