Реакция #76684

Уравнение реакции

4-cyano-5-ethoxymethyleneaminooxazole

2-aminoindan

→

title compound

Выход 14.7%

7-(2-Indanylamino)oxazolo[5,4-d]pyrimidine

Выход 14.7%

Растворители

ethanol

Условия реакции

Обработка

1. 1
   Температураto reflux for 6.5 hours
2. 2
   ДругоеThe residue obtained
3. 3
   workup.DISTILLATIONby distilling off the solvent under reduced pressure
4. 4
   Другоеwas purified by silica gel chromatography (methylene chloride:ethyl acetate=1:4)

Методика

4-cyano-5-ethoxymethyleneaminooxazole (240 mg, 1.5 mmol) (see, J. Am. Chem. Soc., 88, 3829 (1966), Bull. Chem. Soc. JAPAN, 43, 187 (1970), Bull. Chem. Soc. JAPAN, 43, 3909 (1970)) and 2-aminoindan (580 mg, 4.4 mmol) in dry ethanol (2 ml) were heated to reflux for 6.5 hours. The residue obtained by distilling off the solvent under reduced pressure was purified by silica gel chromatography (methylene chloride:ethyl acetate=1:4) to obtain the title compound (56 mg, 0.22 mmol) having the following physical properties:

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