Реакция #76676

Уравнение реакции

4-chloro-5-methylthieno[2,3-d]pyrimidine

2-aminoindan

→

title compound

Выход 100.0%

4-(2-Indanylamino)-5-methylthieno[2,3-d]pyrimidine

Выход 100.0%

Растворители

ethanol

Условия реакции

Обработка

1. 1
   Температураto reflux under an argon atmosphere for 40 minutes
2. 2
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure
3. 3
   Другоеthe residue obtained
4. 4
   Другоеwas purified by silica gel chromatography (hexane:ethyl acetate=5:1)

Методика

4-chloro-5-methylthieno[2,3-d]pyrimidine (92 mg, 0.50 mmol) (see J. Pharm. Soc. JAPAN, 109, 464 (1989)) and 2-aminoindan (330 mg, 2.5 mmol) in dry ethanol (1 ml) were heated to reflux under an argon atmosphere for 40 minutes. The solvent was distilled off under reduced pressure and the residue obtained was purified by silica gel chromatography (hexane:ethyl acetate=5:1) to obtain the title compound (140 mg, 0.50 mmol) having the following physical properties:

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