Реакция #76675

Уравнение реакции

water

2-aminoindan

acetic anhydride

→

2-acetamidoindan

Выход 71.1%

Растворители

—

ice water

pyridine

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas added dropwise
2. 2
   Другоеwas returned to room temperature
3. 3
   ФильтрацияThe precipitate that deposited was filtered

Методика

2-aminoindan (6.0 g, 45 mmol) was dissolved in dry pyridine (7 ml), to which acetic anhydride (4.5 ml, 47.3 mmol) was added dropwise while cooling in ice water. After the reaction mixture was returned to room temperature and stirred for 20 minutes, water was added. The precipitate that deposited was filtered to obtain 2-acetamidoindan (5.6 g, 32 mmol).

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