Реакция #76562

Уравнение реакции

ethyl 7-fluoro-4-hydroxy-3-quinolinecarboxylate

→

7-fluoro-4-hydroxy-3-quinolinecarboxylic acid

Выход 92.2%

Растворители

sodium hydroxide

Условия реакции

Обработка

1. 1
   Температураwas heated
2. 2
   Температураat reflux for 3 hours during which time a solution
3. 3
   Другоеwas obtained
4. 4
   Фильтрацияit was filtered
5. 5
   Фильтрацияthrough filter paper under vacuum
6. 6
   ДругоеThe resulting precipitate was collected
7. 7
   Промывкаwashed with water
8. 8
   Другоеdried

Методика

A suspension of ethyl 7-fluoro-4-hydroxy-3-quinolinecarboxylate (65 g, 0.28 mol) in 10% sodium hydroxide (250 mL) was heated at reflux for 3 hours during which time a solution was obtained. The reaction mixture was allowed to cool to ambient temperature and then it was filtered through filter paper under vacuum. The filtrate was acidified with concentrated hydrochloric acid. The resulting precipitate was collected, washed with water and then dried to provide 53.5 g of 7-fluoro-4-hydroxy-3-quinolinecarboxylic acid as a white solid.

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