Реакция #76390

Уравнение реакции

4-(5,5,6,6,7,7,8,8,8-nonafluoro-octyl)-cyclohex-3-enecarboxylic acid ethyl ester

4-(5,5,6,6,7,7,8,8,8-Nonafluoro-octyl)-cyclohex-3-enecarboxylic Acid Ethyl Ester

potasium hydroxide

→

4-(5,5,6,6,7,7,8,8,8-nonafluoro-octyl)-cyclohex-3-enecarboxylic acid

Выход 93.0%

Растворители

water ethanol

Условия реакции

Обработка

1. 1
   Другоеquenched with hydrochloric acid (5%)
2. 2
   Фильтрацияfiltered
3. 3
   Другоеresulted white solid
4. 4
   Промывкаwashed with water
5. 5
   Другоеdried under vacuum

Методика

A solution 4-(5,5,6,6,7,7,8,8,8-nonafluoro-octyl)-cyclohex-3-enecarboxylic acid ethyl ester (41) (1 equi.) and potasium hydroxide (3.5 equi.) in water-ethanol (1:1) (25 mL/mmole) was stirred at 80 C temperature for 2 h., cooled to room temperature and quenched with hydrochloric acid (5%), filtered resulted white solid, washed with water and dried under vacuum to give 4-(5,5,6,6,7,7,8,8,8-nonafluoro-octyl)-cyclohex-3-enecarboxylic acid (42) as a white solid (93%).

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