Реакция #76376

Уравнение реакции

6-bromo-naphthalene-2-ol

benzyl bromide

→

2-Benzyloxy-6-bromo-naphthalene

Растворители

DMF

cesium carbonate

Условия реакции

Обработка

1. 1
   Другоеquenched with water
2. 2
   Экстракцияextracted with ethyl acetate:hexane (1:1)
3. 3
   Промывкаwashed with brine, over MgSO4
4. 4
   Концентрированиеconcentrated in vacuo

Методика

To the commercially available 6-bromo-naphthalene-2-ol (1) (1 equi.) and benzyl bromide (2) (1 equi.) in DMF (3mL/mmole), cesium carbonate (1.25 equi.) was added at room temperature. The reaction mixture was stirred at that temperature for 24 h, quenched with water, extracted with ethyl acetate:hexane (1:1), washed with brine, over MgSO4, and concentrated in vacuo.

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