Реакция #7628

Уравнение реакции

acetylchloride

2,6-diamino-4-chloro-pyrimidine

cyclohexylisonitrile

thiophene-2-carbaldehyde

→

1-acetyl-5-amino-7-chloro-3-cyclohexylamino-2-thiophene-2-yl-imidazo[1,2-a]pyrimidin-1-ium chloride

Растворители

perchloric acid

Условия реакции

Методика

Example 26 was carried out in accordance with the general directions for synthesis in process step a) from 1.0 ml (0.1 mmol) 2,6-diamino-4-chloro-pyrimidine (0.1 M, DCM), 0.575 ml (0.115 mmol) cyclohexylisonitrile solution (0.2 M, DCM), 0.500 ml (0.15 mmol) thiophene-2-carbaldehyde solution (0.3 M, DCM) and 10 μl perchloric acid (w=20%) and in process step c) and d) by reacting the resultant reaction product with 0.4 mmol acetylchloride.

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