Реакция #7598

Уравнение реакции

4,6-dichlorocinnoline

2-fluoro-5-hydroxy-4-methylaniline

→

6-chloro-4-(2-fluoro-5-hydroxy-4-methylanilino)cinnoline hydrochloride

Выход 95.8%

Растворители

2-pentanol

Условия реакции

Обработка

1. 1
   Температураwas heated
2. 2
   Температураat reflux for 45 minutes
3. 3
   ТемператураAfter cooling the solid
4. 4
   Фильтрацияwas filtered off
5. 5
   Промывкаwashed with isopropanol

Методика

A solution of 4,6-dichlorocinnoline (200 mg, 1 mmol) and 2-fluoro-5-hydroxy-4-methylaniline (169 mg, 1.2 mmol), (prepared as described for the starting material in Example 11), in 2-pentanol (4 ml) containing 7M isopropanolic hydrogen chloride (2 drops) was heated at reflux for 45 minutes. After cooling the solid was filtered off, washed with isopropanol followed by ether to give 6-chloro-4-(2-fluoro-5-hydroxy-4-methylanilino)cinnoline hydrochloride (326 mg, 95%).

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