Реакция #7597

Уравнение реакции

4-chloro-6-methoxy-7-[2-(2-methoxyethoxy)ethoxy]cinnoline

2-fluoro-5-hydroxy-4-methylaniline

hydrogen chloride

→

4-(2-fluoro-5-hydroxy-4-methylanilino)-6-methoxy-7-[2-(2-methoxyethoxy)ethoxy]cinnoline

Растворители

2-pentanol

Условия реакции

Обработка

1. 1
   Температураwas heated
2. 2
   Температураat reflux for 45 minutes
3. 3
   ТемператураAfter cooling the solid
4. 4
   Фильтрацияwas filtered off
5. 5
   Промывкаwashed with isopropanol

Методика

A solution of 4-chloro-6-methoxy-7-[2-(2-methoxyethoxy)ethoxy]cinnoline (130 mg, 0.41 mmol) and 2-fluoro-5-hydroxy-4-methylaniline (70 mg, 0.5 mmol), (prepared as described for the starting material in Example 11), in 2-pentanol (3 ml) containing 5M hydrogen chloride in isopropanol (2 drops) was heated at reflux for 45 minutes. After cooling the solid was filtered off, washed with isopropanol followed by ether to give 4-(2-fluoro-5-hydroxy-4-methylanilino)-6-methoxy-7-[2-(2-methoxyethoxy)ethoxy]cinnoline as an hydrochloride salt (159 mg, 88%).

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